Chronic inflammation in the etiology of disease across the life span

D. Furman; J. Campisi; E. Verdin; P. Carrera-Bastos; S. Targ; C. Franceschi; L. Ferrucci; D. Gilroy; A. Fasano; G. Miller; A. Miller; A. Mantovani; C. Weyand; N. Barzilai; J. Goronzy; T. Rando; R. Effros; A. Lucia; N. Kleinstreuer; G. Slavich

Статья

Chronic inflammation in the etiology of disease across the life span

D. Furman, J. Campisi, E. Verdin, P. Carrera-Bastos, S. Targ, C. Franceschi, L. Ferrucci, D. Gilroy, A. Fasano, G. Miller, A. Miller, A. Mantovani, C. Weyand, N. Barzilai, J. Goronzy, T. Rando, R. Effros, A. Lucia, N. Kleinstreuer, G. Slavich,

2021

https://doi.org/10.1038/s41591-019-0675-0

Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI. © 2019, Springer Nature America, Inc.

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1. Version of Record от 2021-04-27

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Об авторах

D. Furman
Buck Institute for Research on Aging, Novato, CA, United States
J. Campisi
Stanford 1000 Immunomes Project, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, United States
E. Verdin
Institute for Research in Translational Medicine, Universidad Austral, CONICET, Pilar, Buenos Aires, Argentina
P. Carrera-Bastos
Iuve Inc., San Mateo, CA, United States
S. Targ
Lawrence Berkeley National Laboratory, Berkeley, CA, United States
C. Franceschi
Center for Primary Health Care Research, Lund University/Region Skåne, Skåne University Hospital, Malmö, Sweden
L. Ferrucci
Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, United States
D. Gilroy
IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy
A. Fasano
Department of Applied Mathematics and Laboratory of Systems Biology of Aging, Lobachevsky University, Nizhny Novgorod, Russian Federation
G. Miller
Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States
A. Miller
Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, London, United Kingdom
A. Mantovani
MassGeneral Hospital for Children, Harvard Medical School, Boston, MA, United States
C. Weyand
Department of Environmental Health Sciences, School of Public Health, Columbia University Medical Center, New York, NY, United States
N. Barzilai
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States
J. Goronzy
Humanitas Clinical and Research Center, Rozzano, Milan, Italy
T. Rando
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
R. Effros
William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University, London, United Kingdom
A. Lucia
Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, United States
N. Kleinstreuer
Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, NY, United States
G. Slavich
Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, United States

Название журнала

Nature Medicine

Том

Выпуск

Страницы

1822-1832

Ключевые слова

biological marker; industrial toxic substance; Article; chronic disease; chronic inflammation; cultural anthropology; diet; disease association; disease predisposition; dysbiosis; environment; health hazard; human; immune response; industry and industrial phenomena; infection; inflammation; life expectancy; lifespan; lifestyle; mental stress; microbiome; non communicable disease; nonhuman; phenotype; physical activity; physical inactivity; pollutant; priority journal; risk factor; social aspect; systemic disease; autoimmune disease; cardiovascular disease; chronic disease; chronic kidney failure; complication; degenerative disease; diabetes mellitus; genetics; inflammation; longevity; neoplasm; nonalcoholic fatty liver; pathophysiology; physiology; Autoimmune Diseases; Cardiovascular Diseases; Chronic Disease; Diabetes Mellitus; Humans; Inflammation; Life Style; Longevity; Neoplasms; Neurodegenerative Diseases; Non-alcoholic Fatty Liver Disease; Renal Insufficiency, Chronic; Risk Factors

Издатель

Nature Research

Тип документа

journal article

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scopus

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Chronic inflammation in the etiology of disease across the life span

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