Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis

P. Zhu; D. Van; D. Falush; N. Brieske; G. Morelli; B. Linz; T. Popovic; I. Schuurman; R. Adegbola; K. Zurth; S. Gagneux; A. Platonov; J. Riou; D. Caugant; P. Nicolas; M. Achtman

Статья

Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis

P. Zhu, D. Van, D. Falush, N. Brieske, G. Morelli, B. Linz, T. Popovic, I. Schuurman, R. Adegbola, K. Zurth, S. Gagneux, A. Platonov, J. Riou, D. Caugant, P. Nicolas, M. Achtman,

2021

https://doi.org/10.1073/pnas.061386098

The genetic variability at six polymorphic loci was examined within a global collection of 502 isolates of subgroup III, serogroup A Neisseria meningitidis. Nine "genoclouds" were identified, consisting of genotypes that were isolated repeatedly plus 48 descendent genotypes that were isolated rarely. These genoclouds have caused three pandemic waves of disease since the mid-1960s, the most recent of which was imported from East Asia to Europe and Africa in the mid-1990s. Many of the genotypes are escape variants, resulting from positive selection that we attribute to herd immunity. Despite positive selection, most escape variants are less fit than their parents and are lost because of competition and bottlenecks during spread from country to country. Competition between fit genotypes results in dramatic changes in population composition over short time periods.

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1. Version of Record от 2021-04-27

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Об авторах

P. Zhu
Max-Planck Institut für Molekulare Genetik, 14195 Berlin, Germany
D. Van
Department of Medical Microbiology, Academic Medical Center, 1105 AZ Amsterdam, Netherlands
D. Falush
Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States
N. Brieske
Medical Research Council Laboratories, Fajara, Gambia
G. Morelli
Swiss Tropical Institute, 4002 Basel, Switzerland
B. Linz
Central Research Institute of Epidemiology, Moscow 111 123, Russian Federation
T. Popovic
Institut Pasteur, 75724 Paris Cedex 15, France
I. Schuurman
World Health Organization, Collaborating Centre for Reference and Research on Meningococci, National Institute of Public Health, N-0403 Oslo, Norway
R. Adegbola
Institut de Médecine Tropicale, Service de Santé des Armées, World Health Organization Collaborating Center for Reference and Research on Meningococci, BP 46, 13998 Marseilles Armées, France
K. Zurth
Center for Biologics, Food and Drug Administration, Rockville, MD 20892, United States
S. Gagneux
45, Rue des Volontaires, 75015 Paris, France
A. Platonov
Max-Planck Institut für Infektionsbiologie, Schumannstrasse 21/22, 10017 Berlin, Germany
J. Riou
D. Caugant
P. Nicolas
M. Achtman

Название журнала

Proceedings of the National Academy of Sciences of the United States of America

Том

Выпуск

Страницы

5234-5239

Ключевые слова

article; epidemic; epidemic meningitis; genetic variability; genotype; Neisseria meningitidis; nonhuman; nucleotide sequence; phylogeny; priority journal; Alleles; Evolution; Gene Frequency; Genes, Dominant; Genotype; Geography; Humans; Meningitis, Meningococcal; Molecular Sequence Data; Mutation; Neisseria meningitidis; Phylogeny; Polymorphism, Genetic; Selection (Genetics); Variation (Genetics); Neisseria meningitidis

Тип документа

journal article

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scopus

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Статья

Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis

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