Статья

The Novel CTX-M-116 β-Lactamase Gene Discovered in Proteus mirabilis Is Composed of Parts of the CTX-M-22 and CTX-M-23 Genes

N. Fursova, S. Pryamchuk, A. Kruglov, I. Abaev, E. Pecherskikh, N. Kartsev, E. Svetoch, I. Dyatlov,
2021

The novel β-lactamase gene blaCTX-M-116 was identified in a Proteus mirabilis nosocomial isolate recovered from the urine of a patient in Moscow in 2005. DNA sequence analysis showed blaCTX-M-116 to be a hybrid gene consisting of 5= blaCTX-M-23 (nucleotides 1 to 278) and 3= blaCTX-M-22 (nucleotides 286 to 876) moieties separated by an intervening putative site of recombination (GTTAAAT). A retrospective analysis of available blaCTX-M genes in the GenBank database revealed 19 blaCTX-M genes that display the same hybrid structure. Copyright © 2013, American Society for Microbiology.

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  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • N. Fursova
    State Research Center for Applied Microbiology and Biotechnology, Obolensk, Russian Federation
  • S. Pryamchuk
    National Agency for Clinical Pharmacology and Pharmacy, Moscow, Russian Federation
  • A. Kruglov
  • I. Abaev
  • E. Pecherskikh
  • N. Kartsev
  • E. Svetoch
  • I. Dyatlov
Название журнала
  • Antimicrobial Agents and Chemotherapy
Том
  • 57
Выпуск
  • 3
Страницы
  • 1552-1555
Ключевые слова
  • bacterial DNA; beta lactamase CTX M; beta lactamase ctx m 116; beta lactamase ctx m 22; beta lactamase ctx m 23; nucleotide; unclassified drug; article; bacterial gene; data base; DNA sequence; gene identification; genetic recombination; hospital infection; hybrid gene; nonhuman; nucleotide sequence; priority journal; Proteus mirabilis; retrospective study; sequence analysis; Base Sequence; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Cross Infection; Databases, Nucleic Acid; Escherichia coli; Escherichia coli Proteins; Humans; Molecular Sequence Data; Protein Isoforms; Proteus Infections; Proteus mirabilis; Recombination, Genetic; Sequence Homology, Nucleic Acid
Тип документа
  • journal article
Источник
  • scopus