Genomic history of the seventh pandemic of cholera in Africa

F. Weill; D. Domman; E. Njamkepo; C. Tarr; J. Rauzier; N. Fawal; K. Keddy; H. Salje; S. Moore; A. Mukhopadhyay; R. Bercion; F. Luquero; A. Ngandjio; M. Dosso; E. Monakhova; B. Garin; C. Bouchier; C. Pazzani; A. Mutreja; R. Grunow; F. Sidikou; L. Bonte; S. Breurec; M. Damian; B. Njanpop-Lafourcade; G. Sapriel; A. Page; M. Hamze; M. Henkens; G. Chowdhury; M. Mengel; J. Koeck; J. Fournier; G. Dougan; P. Grimont; J. Parkhill; K. Holt; R. Piarroux; T. Ramamurthy; M. Quilici; N. Thomson

Статья

Genomic history of the seventh pandemic of cholera in Africa

F. Weill, D. Domman, E. Njamkepo, C. Tarr, J. Rauzier, N. Fawal, K. Keddy, H. Salje, S. Moore, A. Mukhopadhyay, R. Bercion, F. Luquero, A. Ngandjio, M. Dosso, E. Monakhova, B. Garin, C. Bouchier, C. Pazzani, A. Mutreja, R. Grunow, F. Sidikou, L. Bonte, S. Breurec, M. Damian, B. Njanpop-Lafourcade, G. Sapriel, A. Page, M. Hamze, M. Henkens, G. Chowdhury, M. Mengel, J. Koeck, J. Fournier, G. Dougan, P. Grimont, J. Parkhill, K. Holt, R. Piarroux, T. Ramamurthy, M. Quilici, N. Thomson,

2021

https://doi.org/10.1126/science.aad5901

The seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 Vibrio cholerae O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa. © 2017, American Association for the Advancement of Science. All rights reserved.

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1. Version of Record от 2021-04-27

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Об авторах

F. Weill
Institut Pasteur, Unité des Bactéries Pathogènes Entériques, Paris, 75015, France
D. Domman
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, United Kingdom
E. Njamkepo
Centers for Disease Control and Prevention, Escherichia and Shigella Reference Unit, Atlanta, GA 30333, United States
C. Tarr
Centre for Enteric Diseases, National Institute for Communicable Diseases, Johannesburg, 2131, South Africa
J. Rauzier
Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa
N. Fawal
Institut Pasteur, Mathematical Modelling of Infectious Diseases, Paris, 75015, France
K. Keddy
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States
H. Salje
Laboratoire de Parasitologie-Mycologie, CHU Timone, Université de la Méditerranée, Marseille, 13385, France
S. Moore
National Institute of Cholera and Enteric Diseases (NICED), Kolkata, West Bengal 700010, India
A. Mukhopadhyay
Institut Pasteur de Bangui, BP 923, Bangui, Central African Republic
R. Bercion
Institut Pasteur de Dakar, BP 220, Dakar, Senegal
F. Luquero
Epicentre, Paris, 75011, France
A. Ngandjio
Centre Pasteur du Cameroun, BP 1274, Yaoundé, Cameroon
M. Dosso
Bacteriology and Virology Department, Institut Pasteur, Abidjan, Cote d'Ivoire
E. Monakhova
Rostov-on-Don Research Institute for Plague Control, Rostov-on-Don, 344022, Russian Federation
B. Garin
Institut Pasteur, Plate-forme Génomique (PF1), Paris, 75015, France
C. Bouchier
University of Bari A. Moro, Department of Biology, Bari, 70126, Italy
C. Pazzani
Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, CB2 0SP, United Kingdom
A. Mutreja
Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana 121001, India
R. Grunow
Robert Koch Institute, Berlin, 13353, Germany
F. Sidikou
Centre de Recherche Medicale et Sanitaire (CERMES), BP 10887, Niamey, Niger
L. Bonte
Médecins Sans Frontières (MSF), Paris, 75011, France
S. Breurec
Cantacuzino National Institute of Research-Development for Microbiology and Immunology, Bucharest, Romania
M. Damian
Agence de Médecine Préventive (AMP), Paris, 75015, France
B. Njanpop-Lafourcade
Université de Versailles Saint-Quentin-en-Yvelines, UFR des sciences de la santé Simone Veil, Montigny-le-Bretonneux, 78180, France
G. Sapriel
Atelier de Bioinformatique, ISYEB, UMR 7205, Paris, 75005, France
A. Page
Laboratoire Microbiologie Santé et Environnement (LMSE), EDST-FSP, Université Libanaise, Tripoli, Lebanon
M. Hamze
Médecins Sans Frontières, Brussels, B 1050, Belgium
M. Henkens
Centre Hospitalier des Armées Bouffard, Djibouti, Djibouti
G. Chowdhury
Institut Pasteur, Unité du Choléra et des Vibrions, Paris, 75015, France
M. Mengel
Institut Pasteur, Unité Biodiversité des Bactéries Pathogènes Emergentes, Paris, 75015, France
J. Koeck
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia
J. Fournier
London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom
G. Dougan
University Hospital of Pointe-à-Pitre/Abymes, University of Antilles, Pointe-à-Pitre, France
P. Grimont
Hôpital d’Instruction des Armées Robert Picqué, Villenave d’Ornon, France
J. Parkhill
K. Holt
R. Piarroux
T. Ramamurthy
M. Quilici
N. Thomson

Название журнала

Science

Том

Выпуск

6364

Страницы

785-789

Ключевые слова

antibiotics; cholera; drug resistance; epidemic; genomics; periodicity; phylogenetics; Africa; antibiotic sensitivity; Article; bacterial genetics; bacterial genome; bacterium isolate; cholera; human; nonhuman; pandemic; periodicity; phylogeny; priority journal; single nucleotide polymorphism; Vibrio cholerae O1; Asia; cholera; classification; genetics; genomics; isolation and purification; microbiology; Asia; Southern Africa; West Africa; Vibrio cholerae; Africa, Eastern; Africa, Southern; Africa, Western; Asia; Cholera; Genome, Bacterial; Genomics; Humans; Pandemics; Phylogeny; Vibrio cholerae O1

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American Association for the Advancement of Science

Тип документа

journal article

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scopus

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Статья

Genomic history of the seventh pandemic of cholera in Africa

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