Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2

T. Peng; X. Liu; L. Adams; G. Agarwal; B. Akey; J. Cirillo; V. Deckert; S. Delfan; E. Fry; Z. Han; P. Hemmer; G. Kattawar; M. Kim; M. Lee; C. Lu; J. Mogford; R. Nessler; B. Neuman; X. Nie; J. Pan; J. Pryor; N. Rajil; Y. Shih; A. Sokolov; A. Svidzinsky; D. Wang; Z. Yi; A. Zheltikov; M. Scully

Статья

Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2

T. Peng, X. Liu, L. Adams, G. Agarwal, B. Akey, J. Cirillo, V. Deckert, S. Delfan, E. Fry, Z. Han, P. Hemmer, G. Kattawar, M. Kim, M. Lee, C. Lu, J. Mogford, R. Nessler, B. Neuman, X. Nie, J. Pan, J. Pryor, N. Rajil, Y. Shih, A. Sokolov, A. Svidzinsky, D. Wang, Z. Yi, A. Zheltikov, M. Scully,

2021

https://doi.org/10.1063/5.0021842

Lateral flow assay (LFA) has long been used as a biomarker detection technique. It has advantages such as low cost, rapid readout, portability, and ease of use. However, its qualitative readout process and lack of sensitivity are limiting factors. We report a photon-counting approach to accurately quantify LFAs while enhancing sensitivity. In particular, we demonstrate that the density of SARS-CoV-2 antibodies can be quantified and measured with an enhanced sensitivity using this simple laser optical analysis. © 2020 Author(s).

Цитирование

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Версии

1. Version of Record от 2021-04-27

Метаданные

Об авторах

T. Peng
Texas AandM University, College Station, TX 77843, United States
X. Liu
University of Science and Technology of China, Hefei, 230026, China
L. Adams
Leibniz Institute of Photonic Technology, Jena, 07745, Germany
G. Agarwal
Friedrich-Schiller-University Jena, Helmholtzweg 4, Jena, 07743, Germany
B. Akey
Xi'An Jiaotong University, Xi'an, Shaanxi, 710049, China
J. Cirillo
University of Maryland, Baltimore County, Baltimore, MD 21250, United States
V. Deckert
Zhejiang University, Hangzhou, 310027, China
S. Delfan
Moscow State University, Moscow, 119992, Russian Federation
E. Fry
Baylor University, Waco, TX 76798, United States
Z. Han
Princeton University, Princeton, NJ 08544, United States
P. Hemmer
G. Kattawar
M. Kim
M. Lee
C. Lu
J. Mogford
R. Nessler
B. Neuman
X. Nie
J. Pan
J. Pryor
N. Rajil
Y. Shih
A. Sokolov
A. Svidzinsky
D. Wang
Z. Yi
A. Zheltikov
M. Scully

Название журнала

Applied Physics Letters

Том

Выпуск

Страницы

Ключевые слова

Physical properties; Ease-of-use; Enhanced sensitivity; Lateral flow assay; Low costs; Optical analysis; Photon counting; Readout process; Physics

Издатель

American Institute of Physics Inc.

Тип документа

journal article

Источник

scopus

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Статья

Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2

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