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Influenza (H5N1) viruses in poultry, Russian Federation, 2005-2006

A. Lipatov, V. Evseenko, H. Yen, A. Zaykovskaya, A. Durimanov, S. Zolotykh, S. Netesov, I. Drozdov, G. Onishchenko, R. Webster, A. Shestopalov,
2021
https://doi.org/10.3201/eid1304.061266

We studied 7 influenza (H5N1) viruses isolated from poultry in western Siberia and the European part of the Russian Federation during July 2005-February 2006. Full genome sequences showed high homology to Qinghai-like influenza (H5N1) viruses. Phylogenetic analysis not only showed a close genetic relationship between the H5N1 strains isolated from poultry and wild migratory waterfowls but also suggested genetic reassortment among the analyzed isolates. Analysis of deduced amino acid sequences of the M2 and neuraminidase proteins showed that all isolates are potentially sensitive to currently available antiviral drugs. Pathogenicity testing showed that all studied viruses were highly pathogenic in chickens; for 3 isolates tested in mice and 2 tested in ferrets, pathogenicity was heterogeneous. Pathogenicity in mammalian models was generally correlated with Lys at residue 627 of polymerase basic protein 2.

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Источник

Версии

  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • A. Lipatov
    St. Jude Children's Research Hospital, Memphis, TN, United States
  • V. Evseenko
    Federal State Research Institute Research Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation
  • H. Yen
    Federal Service for Surveillance in Consumer Rights Protection and Human Well-being, Moscow, Russian Federation
  • A. Zaykovskaya
    US Department of Agriculture, Athens, GA, United States
  • A. Durimanov
    Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, United States
  • S. Zolotykh
  • S. Netesov
  • I. Drozdov
  • G. Onishchenko
  • R. Webster
  • A. Shestopalov
Название журнала
  • Emerging Infectious Diseases
Том
  • 13
Выпуск
  • 4
Страницы
  • 539-546
Ключевые слова
  • amantadine; antivirus agent; oseltamivir; sialidase; amino acid sequence; article; chicken; controlled study; gene sequence; Influenza virus A H5N1; nonhuman; pathogenicity; phylogeny; poultry; virus isolation
Издатель
  • Centers for Disease Control and Prevention (CDC)
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus
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