Статья

Metabolic and genetic screening of electromagnetic hypersensitive subjects as a feasible tool for diagnostics and intervention

L. De, S. Chung, D. Raskovic, E. Cesareo, D. Caccamo, A. Trukhanov, L. Korkina,
2021

Growing numbers of "electromagnetic hypersensitive" (EHS) people worldwide self-report severely disabling, multiorgan, non-specific symptoms when exposed to low-dose electromagnetic radiations, often associated with symptoms of multiple chemical sensitivity (MCS) and/or other environmental "sensitivity-related illnesses" (SRI). This cluster of chronic inflammatory disorders still lacks validated pathogenetic mechanism, diagnostic biomarkers, and management guidelines. We hypothesized that SRI, not being merely psychogenic, may share organic determinants of impaired detoxification of common physic-chemical stressors. Based on our previous MCS studies, we tested a panel of 12 metabolic blood redox-related parameters and of selected drug-metabolizing-enzyme gene polymorphisms, on 153 EHS, 147 MCS, and 132 control Italians, confirming MCS altered (P<0.05-0.0001) glutathione-(GSH), GSH-peroxidase/S-transferase, and catalase erythrocyte activities. We first described comparable - though milder - metabolic pro-oxidant/proinflammatory alterations in EHS with distinctively increased plasma coenzyme-Q10 oxidation ratio. Severe depletion of erythrocyte membrane polyunsaturated fatty acids with increased ω6/ω3 ratio was confirmed in MCS, but not in EHS. We also identified significantly (P=0.003) altered distribution-versus- control of the CYP2C191/2 SNP variants in EHS, and a 9.7-fold increased risk (OR: 95% C.I.=1.3-74.5) of developing EHS for the haplotype (null)GSTT1 + (null)GSTM1 variants. Altogether, results on MCS and EHS strengthen our proposal to adopt this blood metabolic/genetic biomarkers' panel as suitable diagnostic tool for SRI. © 2014 Chiara De Luca et al.

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  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • L. De
    Centre of Innovative Biotechnological Investigations (Cibi-Nanolab), Novoslobodskaya Street 36/1, Moscow 127055, Russian Federation
  • S. Chung
    Active Longevity Clinic Institut Krasoty Na Arbate, 8 Maly Nikolopeskovsky lane, Moscow 119002, Russian Federation
  • D. Raskovic
    Natural Health Farm, Temasya Industrial Park, 39 Jln Pengacara U1/48, Seksyen U1, 40150 Shah Alam, Selangor, Malaysia
  • E. Cesareo
    2nd Dermatology Division, Dermatology Institute (IDI IRCCS), Via Monti di Creta 104, 00167 Rome, Italy
  • D. Caccamo
    Department of Biomedical Sciences and Morpho-Functional Imaging, Polyclinic University of Messina, 98125 Messina, Italy
  • A. Trukhanov
  • L. Korkina
Название журнала
  • Mediators of Inflammation
Том
  • 2014
Страницы
  • -
Ключевые слова
  • alpha tocopherol; catalase; cytochrome P450; cytochrome P450 2C19; cytochrome P450 2C9; cytochrome P450 2D6; glutathione; glutathione peroxidase; glutathione transferase M1; glutathione transferase P1; glutathione transferase T1; polyunsaturated fatty acid; superoxide dismutase; genetic marker; reactive oxygen metabolite; adult; aged; allele; article; body mass; controlled study; DNA polymorphism; electromagnetic field; electromagnetic hypersensitivity; erythrocyte membrane; female; genetic screening; genotype; haplotype; human; hypersensitivity; major clinical study; male; metabolic parameters; multiple chemical sensitivity; radiation exposure; self report; adolescent; electromagnetic field; genetic marker; genetic polymorphism; genetics; metabolism; middle aged; multiple chemical sensitivity; oxidation reduction reaction; procedures; young adult; Adolescent; Adult; Aged; Electromagnetic Phenomena; Female; Genetic Markers; Genetic Testing; Humans; Male; Middle Aged; Multiple Chemical Sensitivity; Oxidation-Reduction; Polymorphism, Genetic; Reactive Oxygen Species; Young Adult
Издатель
  • Hindawi Publishing Corporation
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus