Поиск по репозиторию
Статья
Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors
2021
This Letter describes the synthesis and antiviral activity study of some glycyrrhizic acid (GL) derivatives against influenza A/H1N1/pdm09 virus in MDCK cells. Conjugation of GL with l-amino acids or their methyl esters, and amino sugar (d-galactose amine) dramatically changed its activity. The most active compounds were GL conjugates with aromatic amino acids methyl esters (phenylalanine and tyrosine) (SI = 61 and 38), and S-benzyl-cysteine (SI = 71). Thus modification of GL is a perspective route in the search of new antivirals, and some of GL derivatives are potent as anti-influenza A/H1N1 agents. © 2015 Elsevier Ltd. All rights reserved.
Цитирование
Похожие публикации
Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Bioorganic and Medicinal Chemistry Letters
Том
- 25
Выпуск
- 8
Страницы
- 1742-1746
Ключевые слова
- antivirus agent; glycyrrhizic acid; animal; cell survival; chemistry; dog; drug effects; Influenza A virus (H1N1); MDCK cell line; physiology; synthesis; virus replication; Animals; Antiviral Agents; Cell Survival; Dogs; Glycyrrhizic Acid; Influenza A Virus, H1N1 Subtype; Madin Darby Canine Kidney Cells; Virus Replication
Издатель
- Elsevier Ltd
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
