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Статья
First detection of an enterovirus C99 in a captive chimpanzee with acute flaccid paralysis, from the tchimpounga chimpanzee rehabilitation center, Republic of Congo
2021
Enteroviruses, members of the Picornaviridae family, are ubiquitous viruses responsible for mild to severe infections in human populations around the world. In 2010 Pointe-Noire, Republic of Congo recorded an outbreak of acute flaccid paralysis (AFP) in the humans, caused by wild poliovirus type 1 (WPV1). One month later, in the Tchimpounga sanctuary near Pointe-Noire, a chimpanzee developed signs similar to AFP, with paralysis of the lower limbs. In the present work, we sought to identify the pathogen, including viral and bacterial agents, responsible for this illness. In order to identify the causative agent, we evaluated a fecal specimen by PCR and sequencing. A Human enterovirus C, specifically of the EV-C99 type was potentially responsible for the illness in this chimpanzee. To rule out other possible causative agents, we also investigated the bacteriome and the virome using next generation sequencing. The majority of bacterial reads obtained belonged to commensal bacteria (95%), and the mammalian virus reads matched mainly with viruses of the Picornaviridae family (99%), in which enteroviruses were the most abundant (99.6%). This study thus reports the first identification of a chimpanzee presenting AFP most likely caused by an enterovirus and demonstrates once again the cross-species transmission of a human pathogen to an ape. Copyright © 2015 Mombo et al.
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- PLoS ONE
Том
- 10
Выпуск
- 8
Страницы
- -
Ключевые слова
- glucose; vitamin B group; Article; bacterial genome; bacterium detection; chimpanzee; Congo; dysphonia; Enterovirus; Enterovirus C99; feces analysis; female; fever; flaccid paralysis; juvenile animal; myalgia; myasthenia; next generation sequencing; nonhuman; Picornaviridae; polymerase chain reaction; quadriplegia; sequence analysis; virus detection; virus genome; virus transmission; animal; Enterovirus C; Enterovirus Infections; epidemic; feces; high throughput sequencing; human; isolation and purification; microbiology; Pan troglodytes; paralysis; pathogenicity; Poliomyelitis virus; virology; Animals; Congo; Disease Outbreaks; Enterovirus C, Human; Enterovirus Infections; Feces; High-Throughput Nucleotide Sequencing; Humans; Pan troglodytes; Paralysis; Poliovirus
Издатель
- Public Library of Science
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
