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Статья
Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach
2021
A biomass-derived platform chemical was utilized to access a demanded pharmaceutical substance with anti-HIV activity (HIV, human immunodeficiency virus) and a variety of structural analogues. Step economy in the synthesis of the drug core (single stage from cellulose) is studied including flexible variability of four structural units. The first synthesis and X-ray structure of the inhibitor of HIV-1 capsid protein assembly (CAP-1) is described. © The Royal Society of Chemistry.
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Organic and Biomolecular Chemistry
Том
- 14
Выпуск
- 45
Страницы
- 10593-10598
Ключевые слова
- Biosynthesis; Proteins; Viruses; Anti-HIV activity; Capsid proteins; Human immunodeficiency virus; Platform chemicals; Single stage; Structural analogue; Structural unit; X-ray structure; Diseases; anti human immunodeficiency virus agent; capsid protein; cellulose; analogs and derivatives; antagonists and inhibitors; biomass; chemistry; drug effects; human; Human immunodeficiency virus 1; Human immunodeficiency virus infection; metabolism; molecular model; synthesis; X ray crystallography; Anti-HIV Agents; Biomass; Capsid Proteins; Cellulose; Crystallography, X-Ray; HIV Infections; HIV-1; Humans; Models, Molecular
Издатель
- Royal Society of Chemistry
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
