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Статья
Analysis of the env gene variability of the IDU-A HIV-1 variant in the outbreak of the HIV infection epidemic in Perm region of Russia (1996-2011)
2021
In the present work, a total of 132 HIV-1 env gene C2-V3-C3 sequences belonging to the IDU-A genetic variant were analyzed. The variants were obtained from the viruses circulating among IDUs and heterosexuals in the Perm region at different periods. It was shown that the rate of the divergence of the IDU-A HIV-1 viruses from a common ancestor increased 4.3 times (p < 0.001) in 2C11 as compared with the onset of the epidemics. The rate of the HIV-1 evolution was different in the two risk groups of the infection. The mean genetic distance of HIV-1 variants circulating among heterosexuals was 1.3 times longer (p = 0.008) than that among IDUs. The accumulation rate of the nucleotide (including nonsynonymous) substitutions in the C2-V3-C3 HIV-1 env gene region among individuals infected by heterosexual contacts was 1.7 times higher than that among IDUs. The differences in the positions of the codons subjected to positive selection were demonstrated depending on the Infection risk group tested.
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Voprosy Virusologii
Том
- 61
Выпуск
- 5
Страницы
- 222-229
Ключевые слова
- virus envelope protein; adult; classification; codon; epidemic; female; gene expression; genetic selection; genetic variation; genetics; heterosexuality; human; Human immunodeficiency virus 1; Human immunodeficiency virus infection; male; mutation rate; phylogeny; Russian Federation; substance abuse; transmission; virology; Adult; Codon; Disease Outbreaks; env Gene Products, Human Immunodeficiency Virus; Female; Gene Expression; Genetic Variation; Heterosexuality; HIV Infections; HIV-1; Humans; Male; Mutation Rate; Phylogeny; Russia; Selection, Genetic; Substance Abuse, Intravenous
Издатель
- Meditsina Publishers
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
