Статья

Candidate SNP markers of gender-biased autoimmune complications of monogenic diseases are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters

M. Ponomarenko, O. Arkova, D. Rasskazov, P. Ponomarenko, L. Savinkova, N. Kolchanov,
2021

Some variations of human genome [for example, single nucleotide polymorphisms (SNPs)] are markers of hereditary diseases and drug responses. Analysis of them can help to improve treatment. Computer-based analysis of millions of SNPs in the 1000 Genomes project makes a search for SNP markers more targeted. Here, we combined two computer-based approaches: DNA sequence analysis and keyword search in databases. In the binding sites for TATA-binding protein (TBP) in human gene promoters, we found candidate SNP markers of gender-biased autoimmune diseases, including rs1143627 [cachexia in rheumatoid arthritis (double prevalence among women)]; rs11557611 [demyelinating diseases (thrice more prevalent among young white women than among non-white individuals)]; rs17231520 and rs569033466 [both: Atherosclerosis comorbid with related diseases (double prevalence among women)]; rs563763767 [Hughes syndrome-related thrombosis (lethal during pregnancy)]; rs2814778 [autoimmune diseases (excluding multiple sclerosis and rheumatoid arthritis) underlying hypergammaglobulinemia in women]; rs72661131 and rs562962093 (both: Preterm delivery in pregnant diabetic women); and rs35518301, rs34166473, rs34500389, rs33981098, rs33980857, rs397509430, rs34598529, rs33931746, rs281864525, and rs63750953 (all: Autoimmune diseases underlying hypergammaglobulinemia in women). Validation of these predicted candidate SNP markers using the clinical standards may advance personalized medicine. © 2016 Ponomarenko, Arkova, Rasskazov, Ponomarenko, Savinkova and Kolchanov.

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  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • M. Ponomarenko
    Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russian Federation
  • O. Arkova
    Novosibirsk State University, Novosibirsk, Russian Federation
  • D. Rasskazov
    Children's Hospital Los Angeles, Los Angeles, CA, United States
  • P. Ponomarenko
  • L. Savinkova
  • N. Kolchanov
Название журнала
  • Frontiers in Immunology
Том
  • 7
Выпуск
  • APR
Страницы
  • -
Ключевые слова
  • TATA binding protein; antiphospholipid syndrome; Article; atherosclerosis; cachexia; demyelinating disease; DNA sequence; drug protein binding; gene expression; Graves disease; human; hypergammaglobulinemia; monogenic disorder; multiple sclerosis; personalized medicine; pregnancy diabetes mellitus; premature labor; rheumatoid arthritis; sequence analysis; single nucleotide polymorphism; thalassemia; thrombosis
Издатель
  • Frontiers Media S.A.
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus