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Статья
Five distinct reassortants of H5N6 highly pathogenic avian influenza A viruses affected Japan during the winter of 2016–2017
2021
To elucidate the evolutionary pathway, we sequenced the entire genomes of 89 H5N6 highly pathogenic avian influenza viruses (HPAIVs) isolated in Japan during winter 2016–2017 and 117 AIV/HPAIVs isolated in Japan and Russia. Phylogenetic analysis showed that at least 5 distinct genotypes of H5N6 HPAIVs affected poultry and wild birds during that period. Japanese H5N6 isolates shared a common genetic ancestor in 6 of 8 genomic segments, and the PA and NS genes demonstrated 4 and 2 genetic origins, respectively. Six gene segments originated from a putative ancestral clade 2.3.4.4 H5N6 virus that was a possible genetic reassortant among Chinese clade 2.3.4.4 H5N6 HPAIVs. In addition, 2 NS clusters and a PA cluster in Japanese H5N6 HPAIVs originated from Chinese HPAIVs, whereas 3 distinct AIV-derived PA clusters were evident. These results suggest that migratory birds were important in the spread and genetic diversification of clade 2.3.4.4 H5 HPAIVs. © 2017 The Author(s)
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Virology
Том
- 512
Страницы
- 8-20
Ключевые слова
- Article; bird; chicken; cladistics; genotype; Influenza A virus; Influenza A virus (H5N6); Japan; nonhuman; pathogenicity; phylogeny; phylogeography; poultry; priority journal; Russian Federation; virus gene; virus genome; virus isolation; virus virulence; whole genome sequencing; winter; animal; chicken; genetic reassortment; genetic variation; genetics; Influenza A virus; Influenza in Birds; isolation and purification; virology; Animals; Chickens; Genetic Variation; Influenza A virus; Influenza in Birds; Japan; Phylogeny; Reassortant Viruses
Издатель
- Academic Press Inc.
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
