Статья

Redox biology of respiratory viral infections

O. Khomich, S. Kochetkov, B. Bartosch, A. Ivanov,
2021

Respiratory viruses cause infections of the upper or lower respiratory tract and they are responsible for the common cold—the most prevalent disease in the world. In many cases the common cold results in severe illness due to complications, such as fever or pneumonia. Children, old people, and immunosuppressed patients are at the highest risk and require fast diagnosis and therapeutic intervention. However, the availability and efficiencies of existing therapeutic approaches vary depending on the virus. Investigation of the pathologies that are associated with infection by respiratory viruses will be paramount for diagnosis, treatment modalities, and the development of new therapies. Changes in redox homeostasis in infected cells are one of the key events that is linked to infection with respiratory viruses and linked to inflammation and subsequent tissue damage. Our review summarizes current knowledge on changes to redox homeostasis, as induced by the different respiratory viruses. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.

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Версии

  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • O. Khomich
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str, 32, Moscow, 119991, Russian Federation
  • S. Kochetkov
    Inserm U1052, Cancer Research Center Lyon, University of Lyon, Lyon, 69000, France
  • B. Bartosch
    DevWeCan Laboratories of Excellence Network (Labex), Lyon, 69003, France
  • A. Ivanov
Название журнала
  • Viruses
Том
  • 10
Выпуск
  • 8
Страницы
  • -
Ключевые слова
  • antioxidant; caspase 9; cytochrome P450 reductase; dual oxidase; extracellular superoxide dismutase; glutathione; inducible nitric oxide synthase; intercellular adhesion molecule 1; monocyte chemotactic protein 1; pleconaril; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide phosphate oxidase; rupintrivir; tumor necrosis factor receptor associated factor 6; vapendavir; virus hemagglutinin; virus sialidase; xanthine oxidase; NFE2L2 protein, human; reactive oxygen metabolite; transcription factor Nrf2; antioxidant responsive element; chronic obstructive lung disease; clinical feature; cytokine production; gene expression; human; Human immunodeficiency virus; Human respiratory syncytial virus; Human rhinovirus; Influenza virus; lower respiratory tract; lung fibrosis; lung injury; nonhuman; oxidation reduction reaction; oxidative stress; Pneumovirinae; protein phosphorylation; respiratory virus; Review; Rhinovirus infection; scavenging system; Sendai virus; viral respiratory tract infection; virus entry; virus replication; animal; genetics; immunology; inflammation; metabolism; mouse; Orthomyxoviridae; oxidative stress; physiology; Pneumovirus; respiratory syncytial virus infection; respiratory tract infection; Rhinovirus; virology; virus pneumonia; Animals; Humans; Inflammation; Mice; NF-E2-Related Factor 2; Orthomyxoviridae; Oxidation-Reduction; Oxidative Stress; Pneumonia, Viral; Reactive Oxygen Species; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Respiratory Tract Infections; Rhinovirus
Издатель
  • MDPI AG
Тип документа
  • Review
Тип лицензии Creative Commons
  • CC
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus