COVID-19.рф: ИНФОРМАЦИЯ ПРОТИВ ПАНДЕМИИ

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Статья

Comparative analysis of B-Cell receptor repertoires induced by live yellow fever vaccine in young and middle-Age donors

A. Davydov, A. Obraztsova, M. Lebedin, M. Turchaninova, D. Staroverov, E. Merzlyak, G. Sharonov, O. Kladova, M. Shugay, O. Britanova, D. Chudakov,
2021
https://doi.org/10.3389/fimmu.2018.02309

Age-related changes can significantly alter the state of adaptive immune system and often lead to attenuated response to novel pathogens and vaccination. In present study we employed 5′RACE UMI-based full length and nearly error-free immunoglobulin profiling to compare plasma cell antibody repertoires in young (19-26 years) and middle-Age (45-58 years) individuals vaccinated with a live yellow fever vaccine, modeling a newly encountered pathogen. Our analysis has revealed age-related differences in the responding antibody repertoire ranging from distinct IGH CDR3 repertoire properties to differences in somatic hypermutation intensity and efficiency and antibody lineage tree structure. Overall, our findings suggest that younger individuals respond with a more diverse antibody repertoire and employ a more efficient somatic hypermutation process than elder individuals in response to a newly encountered pathogen. © 2007 - 2018 Frontiers Media S.A. All Rights Reserved.

Цитирование

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Источник

Версии

  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • A. Davydov
    Adaptive Immunity Group, Central European Institute of Technology, Brno, Czech Republic
  • A. Obraztsova
    Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russian Federation
  • M. Lebedin
    Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russian Federation
  • M. Turchaninova
    Genomics of Adaptive Immunity Department, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation
  • D. Staroverov
    Pirogov Russian National Research Medical University, Department of Molecular Technologies, Moscow, Russian Federation
  • E. Merzlyak
    Privolzhsky Research Medical University, Laboratory of Genomics of Antitumor Adaptive Immunity, Nizhny Novgorod, Russian Federation
  • G. Sharonov
  • O. Kladova
  • M. Shugay
  • O. Britanova
  • D. Chudakov
Название журнала
  • Frontiers in Immunology
Том
  • 9
Выпуск
  • OCT
Страницы
  • -
Ключевые слова
  • immunoglobulin heavy chain; lymphocyte antigen receptor; virus antibody; yellow fever vaccine; active immunization; adult; animal; B lymphocyte; female; genetics; human; immunoglobulin constant region; immunology; male; metabolism; middle aged; somatic hypermutation; vaccination; yellow fever; young adult; Adult; Animals; Antibodies, Viral; B-Lymphocytes; Female; Humans; Immunity, Active; Immunoglobulin Constant Regions; Immunoglobulin Heavy Chains; Male; Middle Aged; Receptors, Antigen, B-Cell; Somatic Hypermutation, Immunoglobulin; Vaccination; Yellow Fever; Yellow Fever Vaccine; Young Adult
Издатель
  • Frontiers Media S.A.
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus
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