Статья

The effectiveness of combination antihypertensive therapy in patients with arterial hypertension and additional risk factors: Obesity and obstructive sleep apnea syndrome [Эффективность комбинированной антигипертензивной терапии у пациентов с артериальной гипертензией и дополнительными факторами риска: ожирением и синдромом обструктивного апноэ сна]

E. Elfimova, L. Yu, I. Chazova,
2021

Aim. To study the effectiveness of a fixed combination of perindopril and amlodipine, with the subsequent addition of indapamide-retard in male patients with arterial hypertension (AH), obesity and severe sleep apnea (OSAS). Materials and methods. The study included 43 male patients in whom antihypertensive therapy titration was performed to achieve target blood pressure values with a fixed combination of calcium antagonist amlodipine (10 mg) and an angiotensin-converting inhibitor perindopril (5–10 mg) and indapamide-retard. At baseline and after 4–6 weeks, the effectiveness of antihypertensive therapy was monitored according to clinical measurements and ambulatory blood pressure monitoring (ABPM). An assessment of the carotid-femoral pulse wave velocity (cfPWV), aortic PWV (aoPWV), and ankle-brachial PWV (abPWV) was performed. Results and discussion. Target blood pressure values (according to clinical blood pressure, 24-hour blood pressure monitoring) during therapy with amlodipine 10 mg and perindopril 10 mg reached 65% of patients and another 30% reached target blood pressure when adding indapamide-retard 1.5 mg, that is – 95% of all patients included in the study. Upon reaching the target blood pressure values, a significant decrease in cfPWV, aoPWV and abPWV was observed. Conclusion. The fixed combination of perindopril arginine and amplodipine, with the addition of indapamide retard in male patients with hypertension 1st degree in the presence of obesity and severe OSAS allows to reach effective control of blood pressure and improve the elastic properties of large arteries, which can lead to a favorable organoprotective effect in this category of patients. © 2018 Media Sphera Publishing Group. All rights reserved.

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  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • E. Elfimova
    Institute of Clinical Cardiology, National Medical Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
  • L. Yu
  • I. Chazova
Название журнала
  • Terapevticheskii Arkhiv
Том
  • 90
Выпуск
  • 12
Страницы
  • 28-33
Ключевые слова
  • antihypertensive agent; indapamide; perindopril; blood pressure; blood pressure monitoring; complication; drug combination; human; hypertension; male; obesity; pulse wave; sleep disordered breathing; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Drug Combinations; Humans; Hypertension; Indapamide; Male; Obesity; Perindopril; Pulse Wave Analysis; Sleep Apnea, Obstructive
Издатель
  • CJSC Consilium Medicum
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus