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Статья
Transcriptomic analysis of covid-19 lungs and bronchoalveolar lavage fluid samples reveals predominant b cell activation responses to infection
2021
The outbreak of the 2019 coronavirus disease (named, COVID-19), caused by the novel SARS-coV-2 virus, represents a worldwide severe threat to public health. It is of the utmost importance to characterize the immune responses against the SARS-CoV-2 and the mechanisms of hyperinflammation, in order to design better therapeutic strategies for cOVId-19. In the present study, a transcriptomic analysis was performed to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples from COVID-19 patients and controls. Our data concordantly revealed increased humoral responses to infection. The elucidation of the host responses to SARS-coV-2 infection may further improve our understanding of COVID-19 pathogenesis and suggest better therapeutic strategies. © This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.
Цитирование
Похожие публикации
Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- International Journal of Molecular Medicine
Том
- 46
Выпуск
- 4
Страницы
- 1266-1273
Ключевые слова
- Article; B lymphocyte activation; bronchoalveolar lavage fluid; controlled study; coronavirus disease 2019; human; human cell; human tissue; humoral immunity; immune response; immune system; pathogenesis; priority journal; Severe acute respiratory syndrome coronavirus 2; transcriptomics; virus immunity; B lymphocyte; Betacoronavirus; bronchoalveolar lavage fluid; Coronavirus infection; factual database; female; gene expression regulation; gene regulatory network; genetics; host pathogen interaction; immunology; lung; lymphocyte activation; male; metabolism; pandemic; physiology; virus pneumonia; transcriptome; B-Lymphocytes; Betacoronavirus; Bronchoalveolar Lavage Fluid; Coronavirus Infections; Databases, Factual; Female; Gene Expression Regulation; Gene Regulatory Networks; Host-Pathogen Interactions; Humans; Lung; Lymphocyte Activation; Male; Pandemics; Pneumonia, Viral; Transcriptome
Издатель
- Spandidos Publications
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
