The conundrum of human immune system “senescence”

G. Pawelec; A. Bronikowski; S. Cunnane; L. Ferrucci; C. Franceschi; T. Fülöp; P. Gaudreau; V. Gladyshev; E. Gonos; V. Gorbunova; B. Kennedy; A. Larbi; J. Lemaître; G. Liu; A. Maier; J. Morais; O. Nóbrega; A. Moskalev; M. Rikkert; A. Seluanov; A. Senior; S. Ukraintseva; Q. Vanhaelen; J. Witkowski; A. Cohen

Статья

The conundrum of human immune system “senescence”

G. Pawelec, A. Bronikowski, S. Cunnane, L. Ferrucci, C. Franceschi, T. Fülöp, P. Gaudreau, V. Gladyshev, E. Gonos, V. Gorbunova, B. Kennedy, A. Larbi, J. Lemaître, G. Liu, A. Maier, J. Morais, O. Nóbrega, A. Moskalev, M. Rikkert, A. Seluanov, A. Senior, S. Ukraintseva, Q. Vanhaelen, J. Witkowski, A. Cohen,

2021

https://doi.org/10.1016/j.mad.2020.111357

There is a great deal of debate on the question of whether or not we know what ageing is (Ref. Cohen et al., 2020). Here, we consider what we believe to be the especially confused and confusing case of the ageing of the human immune system, commonly referred to as “immunosenescence”. But what exactly is meant by this term? It has been used loosely in the literature, resulting in a certain degree of confusion as to its definition and implications. Here, we argue that only those differences in immune parameters between younger and older adults that are associated in some definitive manner with detrimental health outcomes and/or impaired survival prospects should be classed as indicators of immunosenescence in the strictest sense of the word, and that in humans we know remarkably little about their identity. Such biomarkers of immunosenescence may nonetheless indicate beneficial effects in other contexts, consistent with the notion of antagonistic pleiotropy. Identifying what could be true immunosenescence in this respect requires examining: (1) what appears to correlate with age, though generality across human populations is not yet confirmed; (2) what clearly is part of a suite of canonical changes in the immune system that happen with age; (3) which subset of those changes accelerates rather than slows aging; and (4) all changes, potentially population-specific, that accelerate agig. This remains an immense challenge. These questions acquire an added urgency in the current SARS-CoV-2 pandemic, given the clearly greater susceptibility of older adults to COVID-19. © 2020 Elsevier B.V.

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1. Version of Record от 2021-04-27

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Об авторах

G. Pawelec
Department of Immunology, University of Tübingen, Tübingen, Germany
A. Bronikowski
Health Sciences North Research Institute, Sudbury, ON, Canada
S. Cunnane
Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA 50011, United States
L. Ferrucci
Department of Medicine and Research Center on Aging, Université de Sherbrooke, Sherbrooke, Québec, Canada
C. Franceschi
National Institute on Aging, 241 Bay View Boulevard, Baltimore, MD 21225, United States
T. Fülöp
Mater Studiorum University of Bologna, Italy
P. Gaudreau
Laboratory of Systems Biology of Healthy Aging, Department of Applied Mathematics, Lobachevsky State University, Nizhny Novgorod, Russian Federation
V. Gladyshev
Department of Medicine, Geriatric Division, University of Sherbrooke, 3001 12 Ave N, Sherbrooke, QC J1H 5N4, Canada
E. Gonos
Research Center on Aging, 1036 Rue Belvédère S, Sherbrooke, QC J1H 4C4, Canada
V. Gorbunova
Department of Medicine, University of Montreal, Montreal, QC, Canada
B. Kennedy
Centre Hospitalier de l'Université de Montréal Research Centre, Montreal, QC, Canada
A. Larbi
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States
J. Lemaître
National Hellenic Research Foundation, Institute of Chemical Biology, Athens, Greece
G. Liu
Departments of Biology and Medicine, University of Rochester, Rochester, NY 14627, United States
A. Maier
Healthy Longevity Programme, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr.117597, Singapore
J. Morais
Centre for Healthy Longevity, National University Health System, 1E Kent Ridge Rd., Singapore, 119228, Singapore
O. Nóbrega
Singapore Institute of Clinical Sciences, A⁎STAR, Singapore, 117609, Singapore
A. Moskalev
Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, United States
M. Rikkert
A⁎STAR, 8 Biomedical Grove, #07, Neuros, Singapore, 138665, Singapore
A. Seluanov
Université de Lyon, Lyon, F-69000, France
A. Senior
Université Lyon 1, CNRS, UMR5558, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, F-69622, France
S. Ukraintseva
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China
Q. Vanhaelen
Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
J. Witkowski
Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands
A. Cohen
Division of Geriatric Medicine, Faculty of Medicine, McGill University and Research Institute of the McGill University Health Centre, Montreal, QC, Canada

Название журнала

Mechanisms of Ageing and Development

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Ключевые слова

aging; anthropometry; Article; autoimmune disease; CD4+ T lymphocyte; CD8+ T lymphocyte; frailty; human; immune system; immunosenescence; infection; malignant neoplasm; morbidity; mortality; nonhuman; outcome assessment; priority journal; sarcopenia; survival; vaccination; adult; aged; epidemiology; immunology; middle aged; pandemic; pathology; therapy; biological marker; Adult; Aged; Biomarkers; COVID-19; Humans; Immunosenescence; Middle Aged; Pandemics; SARS-CoV-2

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Elsevier Ireland Ltd

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journal article

Тип лицензии Creative Commons

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Свободная лицензия

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scopus

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The conundrum of human immune system “senescence”

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