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Статья
Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies
2021
The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has posed a serious threat to global health. As no specific therapeutics are yet available to control disease evolution, more in-depth understanding of the pathogenic mechanisms induced by SARS-CoV-2 will help to characterize new targets for the management of COVID-19. The present study identified a specific set of biological pathways altered in primary human lung epithelium upon SARS-CoV-2 infection, and a comparison with SARS-CoV from the 2003 pandemic was studied. The transcriptomic profiles were also exploited as possible novel therapeutic targets, and anti-signature perturbation analysis predicted potential drugs to control disease progression. Among them, Mitogen-activated protein kinase kinase (MEK), serine-threonine kinase (AKT), mammalian target of rapamycin (mTOR) and I kappa B Kinase (IKK) inhibitors emerged as candidate drugs. Finally, sex-specific differences that may underlie the higher COVID-19 mortality in men are proposed. © 2020 Elsevier B.V.
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Autoimmunity Reviews
Том
- 19
Выпуск
- 7
Страницы
- -
Ключевые слова
- I kappa B kinase; mammalian target of rapamycin; mitogen activated protein kinase kinase; protein serine threonine kinase; transcriptome; MTOR protein, human; target of rapamycin kinase; transcriptome; adult; comparative study; coronavirus disease 2019; disease exacerbation; female; human; human tissue; lung epithelium; male; middle aged; pandemic; Review; Severe acute respiratory syndrome coronavirus 2; sex difference; transcriptomics; virus virulence; Betacoronavirus; cell culture; Coronavirus infection; cytology; drug development; epithelium cell; genetics; lung; mortality; pathology; severe acute respiratory syndrome; sex factor; virology; virus pneumonia; Betacoronavirus; Cells, Cultured; Coronavirus Infections; Drug Discovery; Epithelial Cells; Female; Humans; Lung; Male; Pandemics; Pneumonia, Viral; Severe Acute Respiratory Syndrome; Sex Factors; TOR Serine-Threonine Kinases; Transcriptome
Издатель
- Elsevier B.V.
Тип документа
- Review
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
