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Статья
Comparative thermostability analysis of zoonotic and human influenza virus A and B neuraminidase
2021
Neuraminidase (NA) thermostability of influenza A and B viruses isolated from birds, swine and humans was measured to evaluate its variability associated with host body temperature. The highest 50% inactivation temperature (IT50) was observed with H3N8 avian influenza virus (74 °C), and the lowest IT50 was observed with the seasonal human H3N2 virus (45.5 °C). The IT50 values of A(H1N1)pdm09 viruses 56.4-58.5 °C were statistically higher than that of the prepandemic strain A/Solomon Islands/03/06 (52.5 °C). An analysis of Ca2+ binding sites revealed the correspondence of amino acid changes to NA thermostability. This study demonstrates that changes in NA thermostability correspond to differences in host body temperature. © 2019, Springer-Verlag GmbH Austria, part of Springer Nature.
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Archives of Virology
Том
- 165
Выпуск
- 1
Страницы
- 201-206
Ключевые слова
- sialidase; viral protein; animal; bird; body temperature; chemistry; comparative study; enzyme stability; enzymology; human; Influenzavirus A; Influenzavirus B; pig; thermodynamics; virology; zoonosis; Animals; Birds; Body Temperature; Enzyme Stability; Humans; Influenzavirus A; Influenzavirus B; Neuraminidase; Swine; Thermodynamics; Viral Proteins; Zoonoses
Издатель
- Springer
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
