Поиск по репозиторию
Статья
COVID-19 is an ongoing pandemic caused by the SARS-CoV-2 coronavirus that poses one of the greatest challenges to public health in recent years. SARS-CoV-2 is known to preferentially target older subjects and those with pre-existing conditions, but the reason for this age dependence is unclear. Here, we found that the case fatality rate for COVID-19 grows exponentially with age in all countries tested, with the doubling time approaching that of all-cause human mortality. In addition, men and those with multiple age-related diseases are characterized by increased mortality. Moreover, similar mortality patterns were found for all-cause pneumonia. We further report that the gene expression of ACE2, the SARS-CoV-2 receptor, grows in the lung with age, except for subjects on a ventilator. Together, our findings establish COVID-19 as an emergent disease of aging, and age and age-related diseases as its major risk factors. In turn, this suggests that COVID-19, and deadly respiratory diseases in general, may be targeted, in addition to antiviral approaches, by approaches that target the aging process. © 2020 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd
Цитирование
Похожие публикации
Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Aging Cell
Том
- 19
Выпуск
- 10
Страницы
- -
Ключевые слова
- angiotensin converting enzyme 2; virus receptor; angiotensin converting enzyme 2; dipeptidyl carboxypeptidase; adult; aged; aging; all cause mortality; Article; case fatality rate; controlled study; coronavirus disease 2019; female; gene expression; human; human tissue; immune system; incidence; lung; major clinical study; male; multicenter study; priority journal; risk factor; Severe acute respiratory syndrome coronavirus 2; very elderly; virus pneumonia; virus strain; age; aging; Betacoronavirus; Coronavirus infection; global health; immunology; metabolism; mortality; pandemic; sex factor; virus pneumonia; Age Factors; Aged; Aging; Betacoronavirus; Coronavirus Infections; Female; Global Health; Humans; Male; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Sex Factors
Издатель
- Blackwell Publishing Ltd
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
