The purpose of the article is to identify the main socio-economic causes and consequences of the COVID-19 coronavirus pandemic in indicative planning of the innovative development of a federal state, as well as the ways to overcome the negative consequences as a new and substantial example of impact of unforeseen factors of a radical nature to a federal state. The main fundamental consequences of the COVID-19 coronavirus pandemic appear to be two interrelated innovation processes (coronavirus' affects): accelerated digitalization of all aspects of socioeconomic activity, as well as socio-economic innovation, namely "zeroing", i.e. gradual displacement of a person from many processes where he is currently carrying out labor activities. In order to overcome the negative consequences of the coronavirus pandemic COVID-19 and other unforeseen factors of a radical nature federal states of the countries and region governments are apt use the tools of innovation and indicative planning. © The Authors, published by EDP Sciences, 2020.