The problems of methodology of scientific research activity are actual to-day due to discoveries in Physics, Biology and Cosmology Due to widespread international cooperation and advances in the field of genomics (especially in sequence analysis), as well as major advances in computing technology, a «rough draft» of the genome was finished in 2000. This first available rough draft assembly of the genome was completed by the Genome Bioinformatics Group at the University of California. The OECD Project «Human Genome» is the first experience of application of methodology of scientific research activity based on mathematic modeling and cipher technology. The institutions, companies, and laboratories, engaged in OECD Human Genome Project, form a system based on laws and regulations, treaties and agreements, contracts and regulatory orders. This Model of methodological approach might have been used in other interdisciplinary scientific research activities. The study was carried out with the financial support of the Russian Foundation for Basic Research in the framework of research project No. 18-29-14025 on the topic: "Legal regulation of genomic research and the use of their results: comparative legal aspect of research». © The Authors, published by EDP Sciences, 2020.