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Статья
CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features
2021
T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8+ T cells. Characterization of these TCRs has extended our understanding of the molecular mechanisms that govern the recognition of peptide-HLA. However, few examples exist for CD4+ T cells. Here, we investigate CD4+ T cell responses to the internal proteins of the influenza A virus that correlate with protective immunity. We identify five internal epitopes that are commonly recognized by CD4+ T cells in five HLA-DR1+ subjects and show conservation across viral strains and zoonotic reservoirs. TCR repertoire analysis demonstrates several shared gene usage biases underpinned by complementary biochemical features evident in a structural comparison. These epitopes are attractive targets for vaccination and other T cell therapies. © 2020 The Author(s)CD4+ T cells orchestrate protection from severe influenza. However, knowledge of epitopes and the molecular patterns associated with recognition across the population is lacking. Greenshields-Watson et al. identify several influenza epitopes from internal proteins and use them to explore the biochemical features that underpin CD4+ T cell responses to influenza. © 2020 The Author(s)
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Cell Reports
Том
- 32
Выпуск
- 2
Страницы
- -
Ключевые слова
- epitope; HLA DR1 antigen; viral protein; animal cell; animal experiment; animal model; Article; biochemical analysis; C57BL 6 mouse; CD4+ T lymphocyte; complement system; controlled study; female; genetic selection; immune response; in vitro study; influenza A; male; mouse; nonhuman; priority journal; protein expression; T lymphocyte subpopulation; V gene usage; viral genetic phenomena and functions; virus immunity; virus strain; wild type
Издатель
- Elsevier B.V.
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
