During last years the frequency of invasive pulmonary aspergillosis (IPA) in immunocompetent patients has increased. Clinical case report of successful treatment invasive aspergillosis with influenza A(H1N1) presented in the article. We analyzed the special literature of patients with IPA following influenza infection. The timely identification and treatment of these patients are necessary. © 2020 Interregional public organization Association of infectious disease specialists of Saint-Petersburg and Leningrad region (IPO AIDSSPbR). All rights reserved.