Статья

COVID-19 and iron deficiency anemia: Relationships of pathogenesis and therapy

O. Gromova, I. Torshin, Y. Shapovalova, M. Kurtser, A. Chuchalin,
2021

During pregnancy, a woman becomes more susceptible to respiratory and viral diseases, including novel coronavirus infection (COVID-19). Pregnancy exacerbates the acute inflammation typical to COVID-19, elevating a risk of developing cytokine storm, characterized by an avalanche-like spike of inflammation marker concentrations (C-reactive protein, interleukin-1β, interleukin-6, interferon-γ, ferritin, erythrocyte sedimentation rate etc.). Cytokine storm increases a risk of pregnancy loss and contribute to formation of multiple organ dysfunction syndrome in pregnant women and fetus. In particular, erythrocyte degradation due to acute inflammation leads to hypoxia and uncontrolled inter-tissue iron redistribution. As a result, conditions are created simultaneously for developing pulmonary hemosiderosis and hemosiderosis of other tissues in pregnant woman and fetus, as well as for augmenting iron loss from the body, which exacerbates iron deficiency anemia (IDA). It is important to emphasize that a surge of ferritin level distinctive for severe COVID-19, does not indicate iron overload. Therefore, recommendations to cancel IDA correction and even to use iron chelators in COVID-19 may increase hypoxia and harm the health of pregnant women. © 2020 Limited Liability Company KlinMed Consulting.

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  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • O. Gromova
    Institute of Pharmacoinformatics, Federal Research Center 'Informatics and Management', Russian Academy of Sciences, 42 Vavilova Str., Moscow, 119333, Russian Federation
  • I. Torshin
    Big Data Storage and Analysis Center, Lomonosov Moscow State University, 1 Leninskie Gory, Moscow, 119234, Russian Federation
  • Y. Shapovalova
    Lapino Clinic Hospital, MD Medical Group, 1st Uspenskoye Highway, 111, Moscow Region, Odintsovo District, Lapino, 143081, Russian Federation
  • M. Kurtser
    Pirogov Russian National Research Medical University, Health Ministry of Russian Federation, 1 Ostrovityanova Str., Moscow, 117997, Russian Federation
  • A. Chuchalin
Название журнала
  • Obstetrics, Gynecology and Reproduction
Том
  • 14
Выпуск
  • 5
Страницы
  • 644-655
Ключевые слова
  • iron chelating agent; Article; coronavirus disease 2019; human; hypoxia; iron deficiency anemia; pathogenesis; pregnant woman
Издатель
  • IRBIS LLC
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus