Статья

Prospective in-hospital registry of patients with suspected or documented COVID-19 infection and community-acquired pneumonia (TARGET-VIP): characteristics of patients and assessment of in-hospital outcomes [Проспективный госпитальный регистр больных с предполагаемыми или подтвержденными коронавирусной инфекцией COVID-19 и внебольничной пневмонией (ТАРГЕТ-ВИП): характеристика включенных больных и оценка исходов стационарного этапа лечения]

O. Drapkina, O. Karpov, M. Lukyanov, S. Martsevich, A. Pulin, N. Kutishenko, V. Akimkin, E. Andreenko, V. Voronina, V. Dindikova, N. Dmitrieva, A. Zagrebelnyi, O. Lerman, A. Makoveeva, E. Okshina, E. Kudryashov, V. Klyashtorny, A. Smirnov, V. Fomina,
2021

Aim. To characterize patients admitted to hospital with suspected or documented COVID-19 infection and community-acquired pneumonia (CAP) and to assess the prevalence of concomitant cardiovascular, non-cardiac diseases, prehospital cardiovascular therapy and outcomes of in-hospital treatment. Material and methods. The TARGET-VIP registry includes patients admitted to the N.I. Pirogov National Medical and Surgical Center with suspected or documented COVID-19 infection and/or CAP for the period from April 6, 2020 to July 2, 2020. COVID-19 infection was diagnosed using polymerase chain reaction (PCR) tests and chest computed tomography (CT). Comorbid conditions and pre-hospital therapy were assessed. Results. A total of 1,130 patients were included in the registry (mean age, 57,5±12,8 years; men, 579 (51,2%)). Using PCR test, COVID-19 infection was established in 686 (60,7%) patients; using chest CT — 334 (29,6%) patients. The most numerous were the group with a combination of COVID-19 and CAP (n=662; 58,6%) and the group with CAP without positive PCR (n=402; 35,6%). The group of patients with COVID-19 without CAP was the smallest (n=24; 2,1%); in 3,7% of patients (n=42), CAP was not confirmed and PCR were negative. The proportion of people with cardiovascular diseases (CVD) according to the survey, in comparison with data of medical records, was higher by 2% (52,2 vs 50,2%); the proportion of persons with chronic non-cardiac diseases — higher by 6,7% (50,8 vs 44,1%). Among patients with CVD (n=598), compared with patients without CVD (n=532), following diseases was diagnosed significantly more often: diabetes (odds ratio (OR), 5,66; 95% confidence interval (CI), 3,52-9,12), respiratory disease (OR, 2.,7; 95% CI, 1,43-4,27), chronic kidney disease (OR, 3,32; 95% CI, 1,97-5,59), obesity (OR, 15,35; 95% CI, 6,62-35,59). Hospital mortality was 4,2% and significantly differs (4,7 times) in patients with and without COVID-19 according to PCR (6,6 vs 1,4%, p=0,0001), including among patients with CAP and positive or negative PCR (6,0 vs 1,2%, p=0,0002). Conclusion. COVID-19 infection was diagnosed in 60,7% of patients according to PCR and in 90,3% of patients according to the combination of PCR and chest CT. Among patients with CVD, the proportion of people with chronic noncardiac diseases was significantly higher (regardless of age and sex), in particular, with diabetes, chronic kidney disease and obesity. Questionnaires provided important data on the history of noncommunicable diseases and prehospital cardiovascular therapy. The mortality rate of patients with documented COVID-19 infection was 4,7 times higher than with undocumented. © 2020 Vserossiiskoe Obshchestvo Kardiologov. All rights reserved.

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  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • O. Drapkina
    National Research Center for Therapy and Preventive Medicine, Moscow, Russian Federation
  • O. Karpov
    N. I. Pirogov National Medical and Surgical Center, Moscow, Russian Federation
  • M. Lukyanov
    Central Research Institute of Epidemiology, Moscow, Russian Federation
  • S. Martsevich
  • A. Pulin
  • N. Kutishenko
  • V. Akimkin
  • E. Andreenko
  • V. Voronina
  • V. Dindikova
  • N. Dmitrieva
  • A. Zagrebelnyi
  • O. Lerman
  • A. Makoveeva
  • E. Okshina
  • E. Kudryashov
  • V. Klyashtorny
  • A. Smirnov
  • V. Fomina
Название журнала
  • Cardiovascular Therapy and Prevention (Russian Federation)
Том
  • 19
Выпуск
  • 6
Страницы
  • 79-87
Ключевые слова
  • adult; cardiovascular disease; chronic kidney failure; community acquired pneumonia; comorbidity; computer assisted tomography; coronavirus disease 2019; female; hospital mortality; hospital patient; human; major clinical study; male; medical record; mortality rate; outcome assessment; polymerase chain reaction; prevalence; prospective study; questionnaire; Review
Издатель
  • Vserossiiskoe Obshchestvo Kardiologov
Тип документа
  • Review
Тип лицензии Creative Commons
  • CC
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus