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Статья
A bioinformatics model of human diseases on the basis of differentially expressed genes (Of domestic versus wild animals) that are orthologs of human genes associated with reproductive‐potential changes
2021
Earlier, after our bioinformatic analysis of single‐nucleotide polymorphisms of TATA-binding protein‐binding sites within gene promoters on the human Y chromosome, we suggested that human reproductive potential diminishes during self‐domestication. Here, we implemented bioinformatics models of human diseases using animal in vivo genome‐wide RNA‐Seq data to com-pare the effect of co‐directed changes in the expression of orthologous genes on human reproductive potential and during the divergence of domestic and wild animals from their nearest common an-cestor (NCA). For example, serotonin receptor 3A (HTR3A) deficiency contributes to sudden death in pregnancy, consistently with Htr3a underexpression in guinea pigs (Cavia porcellus) during their divergence from their NCA with cavy (C. aperea). Overall, 25 and three differentially expressed genes (hereinafter, DEGs) in domestic animals versus 11 and 17 DEGs in wild animals show the direction consistent with human orthologous gene‐markers of reduced and increased reproductive potential. This indicates a reliable association between DEGs in domestic animals and human orthologous genes reducing reproductive potential (Pearson’s χ2 test p < 0.001, Fisher’s exact test p <0.05, binomial distribution p < 0.0001), whereas DEGs in wild animals uniformly match human orthologous genes decreasing and increasing human reproductive potential (p > 0.1; binomial dis-tribution), thus enforcing the norm (wild type). © 2021 by the author. Licensee MDPI, Basel, Switzerland.
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- International Journal of Molecular Sciences
Том
- 22
Выпуск
- 5
Страницы
- 1-17
Ключевые слова
- 4 aminobutyric acid A receptor; blood clotting factor 7; cholesterol ester transfer protein; cholinergic receptor; dopamine 5 receptor; glial cell line derived neurotrophic factor receptor; growth hormone; interleukin 1beta; neuropilin 2; platelet derived growth factor; platelet derived growth factor A; platelet derived growth factor like protein; prodynorphin; serotonin 3A receptor; serotonin transporter; steroidogenic factor 1; transcriptome; transforming growth factor beta3; unclassified drug; vasculotropin receptor 3; animal experiment; animal model; animal tissue; Article; bioinformatics; blood; canine model; Cavia porcellus; controlled study; domestic animal; domestication; female; frontal cortex; gene expression; genetic difference; guinea pig model; human; hypophysis tissue; in vivo study; male; nonhuman; orthology; rabbit model; rat; RNA sequencing; wild animal
Издатель
- MDPI AG
Тип документа
- journal article
Тип лицензии Creative Commons
- CC
Правовой статус документа
- Свободная лицензия
Источник
- scopus
