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Статья
SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptors
2021
Understanding the hallmarks of the immune response to SARS-CoV-2 is critical for fighting the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID-19 patients and healthy donors sampled both prior to and during the pandemic. Healthy donors examined during the pandemic exhibited increased numbers of SARS-CoV-2-specific T cells, but no humoral response. Their probable exposure to the virus resulted in either asymptomatic infection without antibody secretion or activation of preexisting immunity. In convalescent patients, we observed a public and diverse T cell response to SARS-CoV-2 epitopes, revealing T cell receptor (TCR) motifs with germline-encoded features. Bulk CD4+ and CD8+ T cell responses to the spike protein were mediated by groups of homologous TCRs, some of them shared across multiple donors. Overall, our results demonstrate that the T cell response to SARS-CoV-2, including the identified set of TCRs, can serve as a useful biomarker for surveying antiviral immunity. © 2020 Elsevier Inc.Shomuradova et al. assessed the immune response to SARS-CoV-2 in convalescent patients and healthy donors. Antigen-specific T cells were increased in convalescents and in donors sampled during the pandemic. The work identified two public epitopes from S-glycoprotein. T cell receptor repertoire profiling of S-glycoprotein-specific lymphocytes revealed public CDR3 motifs. © 2020 Elsevier Inc.
Цитирование
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Версии
- 1. Version of Record от 2021-04-27
Метаданные
Название журнала
- Immunity
Том
- 53
Выпуск
- 6
Страницы
- 1245-1257.e5
Ключевые слова
- coronavirus spike glycoprotein; epitope; lymphocyte antigen receptor; virus antibody; adolescent; adult; asymptomatic infection; CD4+ T lymphocyte; CD8+ T lymphocyte; cell culture; convalescence; female; human; immunity; immunological memory; immunology; lymphocyte activation; male; metabolism; middle aged; pandemic; physiology; young adult; Adolescent; Adult; Antibodies, Viral; Asymptomatic Infections; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Convalescence; COVID-19; Epitopes, T-Lymphocyte; Female; Humans; Immunity; Immunologic Memory; Lymphocyte Activation; Male; Middle Aged; Pandemics; Receptors, Antigen, T-Cell; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Young Adult
Издатель
- Cell Press
Тип документа
- journal article
Тип лицензии Creative Commons
- CC BY-NC-ND
Правовой статус документа
- Свободная лицензия
Источник
- scopus
