Статья

Asthma-associated risk for COVID-19 development

C. Skevaki, A. Karsonova, A. Karaulov, M. Xie, H. Renz,
2021

The newly described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for a pandemic (coronavirus disease 2019 [COVID-19]). It is now well established that certain comorbidities define high-risk patients. They include hypertension, diabetes, and coronary artery disease. In contrast, the context with bronchial asthma is controversial and shows marked regional differences. Because asthma is the most prevalent chronic inflammatory lung disease worldwide and SARS-CoV-2 primarily affects the upper and lower airways leading to marked inflammation, the question arises about the possible clinical and pathophysiological association between asthma and SARS-CoV-2/COVID-19. Here, we analyze the global epidemiology of asthma among patients with COVID-19 and propose the concept that patients suffering from different asthma endotypes (type 2 asthma vs non–type 2 asthma) present with a different risk profile in terms of SARS-CoV-2 infection, development of COVID-19, and progression to severe COVID-19 outcomes. This concept may have important implications for future COVID-19 diagnostics and immune-based therapy developments. © 2020 American Academy of Allergy, Asthma & Immunology

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  • 1. Version of Record от 2021-04-27

Метаданные

Об авторах
  • C. Skevaki
    Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps Universität Marburg, German Center for Lung Research (DZL), Marburg, Germany
  • A. Karsonova
    German Center for Lung Research (DZL), Marburg, Germany
  • A. Karaulov
    Department of Clinical Immunology and Allergology, Laboratory of Immunopathology, Sechenov University, Moscow, Russian Federation
  • M. Xie
    Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
  • H. Renz
Название журнала
  • Journal of Allergy and Clinical Immunology
Том
  • 146
Выпуск
  • 6
Страницы
  • 1295-1301
Ключевые слова
  • asthma; human; immunology; pandemic; pathology; Asthma; COVID-19; Humans; Pandemics; SARS-CoV-2
Издатель
  • Mosby Inc.
Тип документа
  • journal article
Тип лицензии Creative Commons
  • CC BY-NC-ND
Правовой статус документа
  • Свободная лицензия
Источник
  • scopus