Thermovaccination – thermoheliox as a stimulator of the immune response. Kinetics of the synthesis of antibodies and C-reactive protein in coronavirus infection

S. Varfolomeev; A. Panin; V. Bykov; S. Tsybenova; S. Zhuravel; A. Ryabokon; I. Utkina; P. Gavrilov; S. Petrikov; L. Shogenova; A. Chuchalin

Статья

Thermovaccination – thermoheliox as a stimulator of the immune response. Kinetics of the synthesis of antibodies and C-reactive protein in coronavirus infection

S. Varfolomeev, A. Panin, V. Bykov, S. Tsybenova, S. Zhuravel, A. Ryabokon, I. Utkina, P. Gavrilov, S. Petrikov, L. Shogenova, A. Chuchalin,

2021

https://doi.org/10.1016/j.cbi.2020.109339

Clinical trials of thermoheliox application (inhalation with a high-temperature mixture of oxygen and helium, 90 °C) in the treatment of the acute phase of coronavirus infection were conducted. Dynamics of disease development in infected patients (PCR test for the virus) and, dynamics of changes in blood concentration of C-reactive protein, immunoglobulin M, specific immunoglobulin G were studied. High efficiency of thermoheliox in releasing the organism from the virus and stimulating the immune response (thermovaccination effect) was shown. The kinetic model of the process is proposed and analyzed. © 2020 Elsevier B.V.

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1. Version of Record от 2021-04-27

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Об авторах

S. Varfolomeev
Institute of Physicochemical Foundations of the Functioning of Neural Network and Artificial Intelligence, Moscow State University, Leninskie Gory, 1–11B, Moscow, 119991, Russian Federation
A. Panin
LLC “MedTechInnovations”, Blagoveshchenskii per, 3-1123001, Russian Federation
V. Bykov
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119334, Russian Federation
S. Tsybenova
N.V. Sklifosovsky Federal Research Institute of Emergency Medicine, Bol'shaya Sukharevskaya Ploshchad’, 3129090, Russian Federation
S. Zhuravel
N.I. Pirogov Russian State National Research Medical University, ul. Ostrovityanova, 1, Moscow, 117997, Russian Federation
A. Ryabokon
Department of Chemistry, Moscow State University, Leninskie Gory, 1–11B, Moscow, 119991, Russian Federation
I. Utkina
P. Gavrilov
S. Petrikov
L. Shogenova
A. Chuchalin

Название журнала

Chemico-Biological Interactions

Том

Страницы

Ключевые слова

C reactive protein; helium; immunoglobulin G; immunoglobulin M; oxygen; virus antibody; adult; aged; biological model; biosynthesis; blood; clinical trial; heat; human; immunology; inhalational drug administration; kinetics; middle aged; procedures; therapy; thermotherapy; vaccination; virology; Administration, Inhalation; Adult; Aged; Antibodies, Viral; C-Reactive Protein; COVID-19; Helium; Hot Temperature; Humans; Hyperthermia, Induced; Immunoglobulin G; Immunoglobulin M; Kinetics; Middle Aged; Models, Immunological; Oxygen; SARS-CoV-2; Vaccination

Издатель

Elsevier Ireland Ltd

Тип документа

journal article

Тип лицензии Creative Commons

CC BY-NC-ND

Правовой статус документа

Свободная лицензия

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scopus

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Статья

Thermovaccination – thermoheliox as a stimulator of the immune response. Kinetics of the synthesis of antibodies and C-reactive protein in coronavirus infection

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