The paper is devoted to the analysis and research of the epidemiological situation in the Bryansk region caused by COVID-19 virus. The main points of the development and testing of the simulation model of epidemic spread are investigated. An algorithm for modeling the epidemiological situation is proposed, an optimization experiment is conducted that gives realistic values based on historical data, and appropriate conclusions are made. The proposed integrated approach allows to reduce the money and time spent on conducting experiments, and also allows to predict the dynamics of coronavirus development in the given region to work out the strategy of health services by using information technologies such as methods of systems simulation. © 2021 Copyright for this paper by its authors. Use permitted under Creative Commons License Attribution 4.0 International (CC BY 4.0).