The relevance of the topic under study is associated with the emergence of completely unfamiliar manifestations of the humanitarian and economic crisis associated with the coronavirus pandemic. The negative impact of its consequences is particularly significant in small and medium enterprises, which include many economic entities of the agro-industrial complex. The purpose of this study is to determine the development factors of interaction between government authorities and agribusiness in terms of ensuring the satisfaction of their interests of both parties in the form of public-private partnership. This determines the objectives of the study: to analyze public-private partnership in the agricultural sector (agro-PPP), its successes and failures, which allows to better represent the achieved level of scientific, methodological and organizational support for the interaction of government and business in Russia; to analyze foreign experience of interaction between government and agribusiness to identify possible risk factors in the PPP mechanism in Russia; to assess the prospects for protection against them in the agricultural sector. The study reveals that effective PPPs operating in the agricultural sector include risk management mechanisms to protect the most vulnerable partners; shows the opportunities for the emergence of additional financial partners in agribusiness partnerships, as well as the need to develop monitoring and assessment of PPP projects in the agro-industrial complex in order to systematically form a reliable information base for developing recommendations for the effective selection of innovative projects and measures their impact in the long term.