Arene-Ruthenium(II) Complexes Containing 11 H-Indeno[1,2- b]quinoxalin-11-one Derivatives and Tryptanthrin-6-oxime: Synthesis, Characterization, Cytotoxicity, and Catalytic Transfer Hydrogenation of Aryl Ketones

V. Matveevskaya; D. Pavlov; T. Sukhikh; A. Gushchin; A. Ivanov; T. Tennikova; V. Sharoyko; S. Baykov; E. Benassi; A. Potapov

Статья

Arene-Ruthenium(II) Complexes Containing 11 H-Indeno[1,2- b]quinoxalin-11-one Derivatives and Tryptanthrin-6-oxime: Synthesis, Characterization, Cytotoxicity, and Catalytic Transfer Hydrogenation of Aryl Ketones

V. Matveevskaya, D. Pavlov, T. Sukhikh, A. Gushchin, A. Ivanov, T. Tennikova, V. Sharoyko, S. Baykov, E. Benassi, A. Potapov,

2020

https://doi.org/10.1021/acsomega.0c01204

A series of novel mono- and binuclear arene-ruthenium(II) complexes [(p-cym)Ru(L)Cl] containing 11H-indeno[1,2-b]quinoxalin-11-one derivatives or tryptanthrin-6-oxime were synthesized and characterized by X-ray crystallography, IR, NMR spectroscopy, cyclic voltammetry, and elemental analysis. Theoretical calculations invoking singlet state geometry optimization, solvation effects, and noncovalent interactions were done using density functional theory (DFT). DFT calculations were also applied to evaluate the electronic properties, and time-dependent DFT was applied to clarify experimental UV-vis results. Cytotoxicity for cancerous and noncancerous human cell lines was evaluated with cell viability MTT assay. Complexes demonstrated a moderate cytotoxic effect toward cancerous human cell line PANC-1. The catalytic activity of the complexes was evaluated in transfer hydrogenation of aryl ketones. All complexes exhibited good catalytic activity and functional group tolerance.

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Версии

1. Version of Record от 2020-05-19

Метаданные

Об авторах

V. Matveevskaya
Tomsk Polytechnic University
D. Pavlov
Tomsk Polytechnic University
T. Sukhikh
Nikolaev Institute of Inorganic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk State University
A. Gushchin
Nikolaev Institute of Inorganic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk State University
A. Ivanov
Saint Petersburg State University
T. Tennikova
Saint Petersburg State University
V. Sharoyko
Saint Petersburg State University
S. Baykov
Saint Petersburg State University
E. Benassi
Shihezi University
A. Potapov
Nikolaev Institute of Inorganic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk State University

Название журнала

ACS Omega

Том

Выпуск

Страницы

11167-11179

Финансирующая организация

Russian Foundation for Basic Research

Номер гранта

18-33-00676

Тип документа

journal article

Тип лицензии Creative Commons

CC BY

Правовой статус документа

Свободная лицензия

Источник

scopus

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Статья

Arene-Ruthenium(II) Complexes Containing 11 H-Indeno[1,2- b]quinoxalin-11-one Derivatives and Tryptanthrin-6-oxime: Synthesis, Characterization, Cytotoxicity, and Catalytic Transfer Hydrogenation of Aryl Ketones

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