Objective: to study the clinical and epidemiological features of influenza in children in the Stavropol Territory. Materials and methods: influenza prevalence is analyzed from 2015 to 2017 the paper used the data from the Territorial Rospotrebnadzor in the Stavropol Territory. We used the following methods: bibliographic, monographic description, epidemiological, analytical, statistical methods. Results: Among the deciphered acute respiratory viral infections, the specific gravity of influenza A (H1N1) 09 in 2016 reached 78%, and in 2017 influenza B prevailed - in 57,4% of children, and influenza A (H3N2) - in 42,6% of cases. In 2016 68,5% of children under 6 years of age, of all admitted, were hospitalized, and in 2017 - 83,86%. We presented the peculiarities of the course of influenza in different epidemic seasons. Conclusion: Unvaccinated children up to 6 years of age have the disease mainly in severe forms and with complications. The epidemic period began to increase in 2015-2016 at week 52, and in 2016-2017 from week 48, ended at week 13 and at week 17. At the epidemic of 2015-2016, intoxication syndrome with chills, microcirculation disturbance, catarrhal syndrome, ARDS prevailed in the clinical picture. The epidemic season of 2016-2017 was characterized by intoxication syndrome, encephalic reaction, hemorrhagic and myalgic syndromes. © 2019 Interregional public organization Association of infectious disease specialists of Saint-Petersburg and Leningrad region (IPO AIDSSPbR). All rights reserved.