Caffeine and cardiovascular diseases: critical review of current research

European Journal of Nutrition volume 55, pages 1331–1343 (2016)Cite this article

Abstract

Caffeine is a most widely consumed physiological stimulant worldwide, which is consumed via natural sources, such as coffee and tea, and now marketed sources such as energy drinks and other dietary supplements. This wide use has led to concerns regarding the safety of caffeine and its proposed beneficial role in alertness, performance and energy expenditure and side effects in the cardiovascular system. The question remains “Which dose is safe?”, as the population does not appear to adhere to the strict guidelines listed on caffeine consumption. Studies in humans and animal models yield controversial results, which can be explained by population, type and dose of caffeine and low statistical power. This review will focus on comprehensive and critical review of the current literature and provide an avenue for further study.

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Affiliations

  1. Centre for Chronic Disease (CCD), College of Health and Biomedicine, Victoria University, Melbourne, VIC, Australia

    Anthony Zulli, Renee M. Smith, Hayley Loftus, Tawar Qaradakhi & Alan Hayes

  2. Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia

    Peter Kubatka

  3. 2nd Department of Internal Medicine, St. Anne’s University Hospital and Masaryk University, Brno, Czech Republic

    Jan Novak & Miroslav Soucek

  4. Department of Physiology, Masaryk University, Brno, Czech Republic

    Jan Novak

  5. Division of Clinical Nutrition, Faculty of Home Economics, Kyoritsu Women’s University, Tokyo, Japan

    Yoshio Uehara

  6. Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic

    Miroslav Pohanka

  7. Bogomolets National Medical University, Kiev, Ukraine

    Nazarii Kobyliak

  8. Cardiology Center Medika, St. Petersburg, Russia

    Angela Zagatina

  9. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Odborarov 10, 832 32, Bratislava, Slovak Republic

    Jan Klimas

  10. Human Anatomy Section, Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy

    Giampiero La Rocca

  11. Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy

    Giampiero La Rocca

  12. Laboratory of Structural Biology and Proteomics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho tr 1/1946, Brno, 612 42, Czech Republic

    Peter Kruzliak

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  1. Anthony Zulli
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Zulli, A., Smith, R.M., Kubatka, P. et al. Caffeine and cardiovascular diseases: critical review of current research. Eur J Nutr 55, 1331–1343 (2016). https://doi.org/10.1007/s00394-016-1179-z

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Keywords

  • Cardiovascular diseases
  • Caffeine
  • Cardioprotective effects
  • Pathogenesis
  • Clinical studies
  • Experimental studies