Type 2 Diabetes Mellitus in Osteoarthritic Patients: Does Association Between Metabolic Impairments, Joint Destruction, and Pain Exist?

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry volume 14, pages 87–104 (2020)Cite this article

Abstract—

Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) are the two most common chronic diseases that have many common epidemiological characteristics, share common risk factors, and are heterogeneous, multifactorial pathologies, which occur on interaction of genetic factors and environmental factors. In addition, these diseases are often occurring in the same patient. Despite the differences in clinical manifestation, both diseases are characterized by similar impairments of cellular metabolism, primarily associated with the energy production and utilization in the form of ATP. The review discusses the molecular mechanisms underlying pathophysiological processes associated with metabolism of glucose and lipids, as well as the ways to overcome impairments of energy metabolism as a new therapeutic approach.

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Funding

This work was partially supported by the Russian Foundation for Basic Research (project no. 09-04-01158-a) “Molecular mechanisms of destruction of articular cartilage in osteoarthritis and methods for its repair: prospects for cartilage regeneration by phenotypic modification of articular chondrocytes.”

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  1. Nasonova Research Institute of Rheumatology, Kashirskoe sh. 34a, 115522, Moscow, Russia

    E. V. Chetina, G. A. Markova & E. P. Sharapova

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  1. E. V. Chetina
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  2. G. A. Markova
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  3. E. P. Sharapova
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Correspondence to E. V. Chetina.

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Translated by A. Medvedev

Abbreviations used: ACC—acetyl-CoA carboxylase; ACLY— ATP citrate lyase; ADAMTS—a disintegrin and metalloproteinase with thrombospondin motifs; AGEs—advanced glycation end products; AMPK—AMP-activated protein kinase; BCAA—branched chain amino acids; BMI—body mass index; COX—cyclooxygenase; CPT—carnitine palmitoyltransferase; DM—diabetes mellitus; GAPDH—glyceraldehyde-3-phosphate dehydrogenase; GLUT—glucose transporter; FA—fatty acids; FFA—free fatty acids; IL—interleukin; IR—insulin resistance; IRS—insulin receptor substrate; MMP—matrix metalloproteinase; MS—metabolic syndrome; mTOR—mechanistic target of rapamycin; n-3PUFAs—n-3 polyunsaturated fatty acids; NGF— nerve growth factor; OA—osteoarthritis; OXPHOS—oxidative phosphorylation; PEPCK—phosphoenolpyruvate carboxykinase; PFK—phosphofructokinase; PFKFB—6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; PGC-1α—proliferation-activated receptor γ coactivator 1α; PGE2—prostaglandin E2; PKM—pyruvate kinase; PPARs—peroxisome proliferator-activated receptors; ROS—reactive oxygen species; TGFβ1—transforming growth factor β1; T1DM—type 1 Diabetes mellitus; T2DM—type 2 Diabetes mellitus; TLR—Toll-like receptors; TNF—tumor necrosis factor.

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Chetina, E.V., Markova, G.A. & Sharapova, E.P. Type 2 Diabetes Mellitus in Osteoarthritic Patients: Does Association Between Metabolic Impairments, Joint Destruction, and Pain Exist?. Biochem. Moscow Suppl. Ser. B 14, 87–104 (2020). https://doi.org/10.1134/S1990750820020043

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Keywords:

  • osteoarthritis
  • diabetes mellitus
  • glucose and lipid metabolism
  • joint destruction
  • pain